The main aim of the study was to investigate the social determinants of health in the Ukrainian female refugee sample in the Czech Republic. The results showed that some determinants of health like financial difficulties and socioeconomic status decline during forced migration, inaccessibility of healthcare services, health deterioration, the presence of chronic diseases, limitation in daily activity due to ill health, experienced discrimination in host country, lack of a person to share personal feelings and issues were significantly associated with poor self-reported physical health status.