Школа громадського здоров’я

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Non-invasive biomarkers for bladder cancer: a study on lncRNAs and DNA methylation
(2025) Haviaz, V.; Bratyshchenko, Anastasiia; Skrypnikova, Olena; Kariaka, S.; Honcharenko, A.; Todoryshyn, D.; Khokhliuk, O.; Rosohatska, I.; Kashuba, Volodymyr; Kononenko, O.; Vikarchuk, Mark; Panasenko, G.; Mankovska, Oksana
Modern diagnostic methods for bladder cancer (BC) have some limitations, including invasiveness and low sensitivity, making the search for new molecular markers important. Aim. To identify potential epigenetic markers for BC diagnosis and progression, including the methylation of gene promoters and the lncRNAs expression levels in tumor tissues and liquid biopsies. Methods. RT-qPCR, MSP. Results. Significant diagnostic value of the VIM, TMEFF2, NKX3.1, MYO3A, GDF15, and RASSF1A methylation in BC patients, increased the RASSF1A expression in tumor tissues and decreased the RASSF1A and ANRASSF1 in liquid biopsies. Correlations were identified between the studied markers and the clinical characteristics of patients. Conclusions. Methylation of the genes VIM, TMEFF2, NKX3.1, MYO3A, GDF15, and RASSF1A, and changes in the expression of the lncRNAs ANRASSF1, PANDAR, and GAS5 may play an important role in BC pathogenesis. The data obtained underscore the relevance of further studies on these markers for BC diagnosis and progression assessment.