Кафедра біології
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Browsing Кафедра біології by Author "Furtat, Iryna"
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Item Antibacterial properties of composite materials based on metal/metal-oxide nanoparticles, nanosilica and polylactid acid(2025) Bespalko, Oleksandr; Vakuliuk, Polina; Furtat, Iryna; Pryshchepa, Oleksandra; Kozakevych, Roman; Pomastowskі, PawełThe global rise in antimicrobial resistance necessitates the development of alternative materials with effective antibacterial properties. This study compares two classes of nanocomposites: silver nanoparticle (AgNP)- and zinc oxide (ZnO)-based systems, both immobilized on silica (SiO₂) and treated with polylactic acid (PLA) to enhance biocompatibility and biodegradability. AgNP-containing composites (SiO₂- Ag and SiO₂-Ag-PLA) exhibited potent, broad-spectrum antibacterial activity, particularly against Gram-negative E. coli and K. pneumoniae, though activity decreased when modified with PLA—likely due to reduced ion release and surface coverage interference.Item Antibacterial properties of silver-containing composite materials based on silica and polylactic acid(2025) Bespalko, Oleksandr; Vakuliuk, Polina; Furtat, Iryna; Pryshchepa, Oleksandra; Kozakevych, Roman; Pomastowskі, PawełThis study aimed to investigate composite materials containing silver nanoparticles (AgNPs) impregnated on silica (SiO2) and incorporated into a polylactic acid (PLA) matrix.Item Antibacterial properties of zinc oxide-containing composite materials based on silica and polylactic acid(ЛНУ імені Івана Франка, 2025) Bespalko, Oleksandr; Vakuliuk, Polina; Furtat, Iryna; Pryshchepa, Oleksandra; Kozakevych, Roman; Pomastowski, PawełAntimicrobial resistance poses a critical threat to global health, as conventional drugs increasingly fail against multidrug-resistant pathogens. A key challenge lies in the inability of many antimicrobials to penetrate microbial membranes or act effectively against intracellular infections. Nanoparticles (NPs) offer a promising alternative due to their unique physicochemical properties and broad-spectrum antimicrobial activity. Among these, zinc oxide nanoparticles (ZnO NPs) are especially notable for their low cytotoxicity and effectiveness against resistant strains.Item Colibacillosis in broiler chicks and its etiological link to the biological characteristics of Escherichia coli isolates from the breeder flock(2025) Nechypurenko, Oleksii; Furtat, Iryna; Dreval, Denis; Avdeeva, LiliyaPathogenic strains of Escherichia coli, capable of causing avian colibacillosis (APEC), currently pose a significant threat to modern poultry farming, in particular industrial broiler production. Moreover, the origin of colibacillosis in broiler chickens is connected with parental health issues. Therefore, the aim of the work was to investigate the etiological link between colibacillosis in 1-day old chicks and the biological characteristics of E. coli isolates from the breeder flock. A total of 65 pathogenic E. coli isolates were detected from broiler-breeders (n = 14) and 1-day-old chikens (n = 51). This shows a huge impact of collibacillosis on poultry farming at different levels of production. The main lesions were associated with fibrin deposition and omphlaitis formation. The last-mentioned parameter could affect the viability of chicks; nevertheless, the average Pasgar score was identified as 9.7 points. Amomg APEC, the most prevalent were O78 and O18 serotypes, wich were characterized by the absence of β-hemolysis. Moreover, the antibiotic profile of APEC isolated from parenteral and progeny flocks was similar. A high level of resistance to amoxicillin, amoxiclav, doxycycline, tetracycline, and enrofloxacin was found; more than 70% of isolated APEC were invulnerable to the mentioned antimicrobials. The most effective antibiotics were colistin, gentamicin, and florfenicol, to which only 0.0% and 2.0%, 14.3 and 9.8%, 7.1% and 2.0% of isolated APEC from broiler-breeders and chickens, respectively, were resistant. In addition, prolonged treatment of birds led to the formation of multi-resistant strains that affected chickens from the first days of life. Thus, studying the process of APEC infection through an integrated production chain can be useful for taking appropriate measures to prevent early cases of colibacilosis.Item Concept of Teaching Academic Biosecurity and Biosafety Disciplines as a Countermeasure to the Main Challenges Under the Conditions of Disinformation War Against Ukraine(2022) Furtat, IrynaDisinformation spreading as part of the hybrid war concept is one of the characteristic features of the modern Russia-Ukraine war. Its peculiarity is that the aggressor country uses various actors and information technologies to defeat its opponents both in the absence of direct armed conflict and during active actions.Item The effectiveness of surfactants as compounds for creating disinfectants with a wide spectrum of action(Національний університет "Києво-Могилянська академія", 2024) Nechypurenko, Oleksii; Furtat, Iryna; Vakuliuk, Polina; Lemeshko, Valentyna; Vortman, Maryna; Shevchenko, ValeriiAlong with the use of antibiotics, the use of disinfectants is crucial in the fighting against multi-resistant strains of bacteria that are dangerous not only for animals but also for humans. A new complex disinfectant could be used as a prevention method. Therefore, the aim of the work was to evaluate the effectiveness surfactants (anionic, cationic and non-ionic) as compounds for the creating of disinfectants with a wide spectrum of action. Compositions with guanidine-containing oligomer (GCO) inhibited S. aureus and C. albicans most effectively. At concentrations of 1000 and 100 ppm, 100 % of cells were inactivated. The biocidal effect against representatives of Gram-negative bacteria was weaker, which should be considered during creation of antimicrobial agents active against pathogenic strains of E. coli. With a rational combination of effective components and their synergism, it is possible to significantly reduce the concentration of the working solution compared to already used commercial disinfectants. For example, the concentration of glutaraldehyde in composition containing 3 % GCO, 1 % Triton X-100, 1 % Trilon B and 1 % glutaraldehyde was in 9 times lower than of Lysoformin 3000. Also, most surfactants used were not characterized by mutagenic activity, which is one of the main criteria for disinfectants usage since this reduces the risks of developing bacterial resistance to antibiotics and other biocides. Thus, the development and implementation of new disinfectants, which could help to fight against multi-resistant strains of bacteria, is an indispensable part of comprehensive programs in controlling and prevention of common diseases in animal husbandry and medicine, particularly, colibacillosis.Item Physicochemical and antibacterial properties of ornidazole based nanocomposites for medical application(2025) Avramenko, Viktoriia; Vakuliuk, Polina; Furtat, Iryna; Pryshchepa, Oleksandra; Kozakevych, Roman; Demianenko, Eugeniy; Murlanova, Tetiana; Smarsly, Bernd; Pomastowskі, PawełThis study analyzed nanocomposites with ornidazole – an antimicrobial agent effective against anaerobic bacteria and protozoa.Item Silica-based Spheres Enriched with Sulfur- and Nitrogen-containing Groups: Transitioning from Adsorbents to Sensory Applications(2024) Stoliarchuk, Nataliia; Tomina, Veronika; Kyshkarova, Viktoriia; Furtat, Iryna; Semeshko, Olha; Seisenbaeva, Gulaim; Melnyk, InnaThe chemical properties at the surface of silica-based materials play a pivotal role in their application effectiveness. The characteristics, positioning, and mixture of surface functional groups directly influence the adsorption properties of these materials. Through a singular synthesis process, it’s possible to create functionalized silica spheres, paving the way for the development of sorbents that are highly efficient in cleaning wastewater from the metallurgy and textile industries or in the precise extraction of precious metals from discarded electronic components.Item Study of guanidine-containing oligomer for desinfectant application(2025) Hodlevskyi, H.; Hudyma, A.; Vakuliuk, Polina; Pryshchepa, Oleksandra; Furtat, Iryna; Vortman, Maryna; Fijalkowski, Pawel; Rafińska, K.; Lemeshko, Valentyna; Murlanova, Tetiana; Smarsly, Bernd; Pomastowskі, Paweł; Shevchenko, V.The purpose of this project is a creation of guanidine containing oligomer, that could be used as a disinfectant against multiresistant microorganisms.Item Synthesis of Tinidazole-Based Nanocomposites and Evaluation of Their Physicochemical Properties(2025) Avramenko, Viktoriia; Vakuliuk, Polina; Furtat, Iryna; Pryshchepa, Oleksandra; Melnykov, V.; Murlanova, Tetiana; Pomastowskі, Paweł; Smarsly, BerndThe aim of the study was to obtain NCs based on nanosilica capable of improving the properties of tinidazole and increasing the safety of its use.