To model the situation with the emissions of air pollutants taking into account the identified trends of the emissions of air pollutants and the main impact factors, the approximation, smoothing dynamics and trend line of Microsoft Excel were applied to determine regression equations and check significance and accuracy of the built models. Statistical modelling of air pollution safety limits was applied as well. To determine the factors affecting emissions of air pollutants, the index of cross-correlation was used. It has been proven that the regional ecological condition impacted by the emissions of air pollutants depends on the priority types of economic activity.