Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological
states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly
developed active surface (SBET ~2700 m2/g) was used as a medical countermeasure (MCM) to acute
radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results
in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow
(BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small
intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation
of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality
of ARS treatment.