The oxidative status in patients with chronic kidney disease
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Date
2020
Authors
Vasylchenko, V.
Korol, L.
Kuchmenko, Olena
Stepanova, N.
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Abstract
An excess of free radicals accompanies the development of renal pathologies and causes numerous
concomitant complications and syndromes. The most common of these are cardiometabolic syndromes in
patients with chronic kidney disease. Therefore, the purpose of the study was to determine the activity of
paraoxonase-1 and myeloperoxidase, which are associated with indicators of high-density lipoproteins content and oxidative stress in the blood of patients with the chronic stage of kidney disease. The activity of the
enzymes, thiobarbiturate-active products concentration and transferrin, ceruloplasmin, thiol compounds
content were determined in the blood of patients with chronic kidney disease. The oxidative status was shown
to be changed. Thus, myeloperoxidase activity, the content of oxidized proteins and the concentration of thiobarbiturate-positive components were increased, while the activity of the antioxidant enzyme paraoxonase-1,
the content of transferrin, ceruloplasmin and thiol compounds were decreased. The ratio of myeloperoxidase
/ paraoxonase-1 activities was progressively increased up to 9-fold, indicating the presence of cardiovascular
complications in patients. The data obtained allowed to extend the range of indicators for monitoring the development of cardiometabolic disorders in the progression of chronic kidney disease.
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Keywords
oxidative status, paraoxonase-1, myeloperoxidase, chronic kidney disease, article
Citation
The oxidative status in patients with chronic kidney disease [electronic resource] / V. S. Vasylchenko, L. V. Korol, O. B. Kuchmenko, N. M. Stepanova // Ukrainian Biochemical Journal. - 2020. - Vol. 92, Issue 5. - P. 70-77.