Nanocomposites with ornidazole-antibacterial and antiadhesive agents against Gram-positive and Gram-negative bacteria
Loading...
Date
2020
Authors
Furtat, Iryna
Lupatsii, M.
Murlanova, Tatiana
Vakuliuk, Polina
Gaidai, Alina
Biliayeva, O.
Sobczuk, Henryk
Golub, Alexander
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Antimicrobial resistance of many microbial species can cause to thousands of deaths worldwide, in this regard new therapeutic strategies have to be invented. To address the question, we have prepared nanocomposites on the basis of pyrogenic
silicon dioxide with ornidazole immobilized on the surface (ornidasil) and studied their antimicrobial properties and the
therapeutic potential. It has also been shown, that in comparison with pure ornidazole the addition of ornidazole to nanocomposite composition can enhance the antimicrobial spectrum, including Gram-positive and Gram-negative bacteria. The
most signifcant bactericidal efect has been reached after more than 24-h treatment with the nanocomposite. Antiadhesive
properties of nanocomposite materials were studied using blood types OO+, AO+, BO+, AB+, the degree of bacterial
adhesion was estimated using three indexes: average adhesion index, index of erythrocytes involvement, index of microbial
adhesion. The efectiveness of the treatment with the nanocomposites obtained was studied on complicated wounds of various etiologies, in particular the wounds caused by diabetic foot syndrome.
Description
Keywords
Antimicrobial nanocomposites, Antiadhesive agents, Highly dispersed silica, Ornidazole, Slow-released drugs, article
Citation
Nanocomposites with ornidazole-antibacterial and antiadhesive agents against Gram-positive and Gram-negative bacteria [electronic resource] / Furtat I., Lupatsii M., Murlanova T., Vakuliuk P., Gaidai A., Biliayeva O., Sobczuk H., Golub A. // Applied Nanoscience. - 2020. - Vol. 10. - P. 3193–3203.