Nanocomposites with ornidazole-antibacterial and antiadhesive agents against Gram-positive and Gram-negative bacteria

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dc.contributor.authorFurtat, Iryna
dc.contributor.authorLupatsii, M.
dc.contributor.authorMurlanova, Tatiana
dc.contributor.authorVakuliuk, Polina
dc.contributor.authorGaidai, Alina
dc.contributor.authorBiliayeva, O.
dc.contributor.authorSobczuk, Henryk
dc.contributor.authorGolub, Alexander
dc.date.accessioned2021-01-23T10:13:24Z
dc.date.available2021-01-23T10:13:24Z
dc.date.issued2020
dc.description.abstractAntimicrobial resistance of many microbial species can cause to thousands of deaths worldwide, in this regard new therapeutic strategies have to be invented. To address the question, we have prepared nanocomposites on the basis of pyrogenic silicon dioxide with ornidazole immobilized on the surface (ornidasil) and studied their antimicrobial properties and the therapeutic potential. It has also been shown, that in comparison with pure ornidazole the addition of ornidazole to nanocomposite composition can enhance the antimicrobial spectrum, including Gram-positive and Gram-negative bacteria. The most signifcant bactericidal efect has been reached after more than 24-h treatment with the nanocomposite. Antiadhesive properties of nanocomposite materials were studied using blood types OO+, AO+, BO+, AB+, the degree of bacterial adhesion was estimated using three indexes: average adhesion index, index of erythrocytes involvement, index of microbial adhesion. The efectiveness of the treatment with the nanocomposites obtained was studied on complicated wounds of various etiologies, in particular the wounds caused by diabetic foot syndrome.en_US
dc.identifier.citationNanocomposites with ornidazole-antibacterial and antiadhesive agents against Gram-positive and Gram-negative bacteria [electronic resource] / Furtat I., Lupatsii M., Murlanova T., Vakuliuk P., Gaidai A., Biliayeva O., Sobczuk H., Golub A. // Applied Nanoscience. - 2020. - Vol. 10. - P. 3193–3203.en_US
dc.identifier.urihttps://doi.org/10.1007/s13204-020-01260-x
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/19302
dc.language.isoenuk_UA
dc.relation.sourceApplied Nanoscience.en_US
dc.statusfirst publisheduk_UA
dc.subjectAntimicrobial nanocompositesen_US
dc.subjectAntiadhesive agentsen_US
dc.subjectHighly dispersed silicaen_US
dc.subjectOrnidazoleen_US
dc.subjectSlow-released drugsen_US
dc.subjectarticleen_US
dc.titleNanocomposites with ornidazole-antibacterial and antiadhesive agents against Gram-positive and Gram-negative bacteriaen_US
dc.typeArticleuk_UA
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