Heparin-binding EGF-like growth factor as a prospective mediator of tissue repair and regeneration
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Date
2024
Authors
Didan, A.
Siromolot, Andriy
Kolybo, Denys
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Abstract
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family. It contains EGF-like and heparin-binding domains allowing interactions with heparin and cell-surface heparin sulfate. [1] It can activate human epidermal growth factor receptors 1 and 4 resulting in a multitude of cell responses, including cellular proliferation, migration, adhesion, and differentiation. HB-EGF levels can increase in response to different forms of injuries as well as extracellular stimuli, such as lysophosphatidic acid, retinoic acid, and 17-estradiol [2]. HB-EGF plays a critical role in tissue repair and regeneration. It promotes cutaneous wound healing, hepatocyte proliferation after partial hepatectomy, intestinal anastomosis strength, alveolar regeneration after pneumonectomy, neurogenesis after ischemic injury, bladder wall thickening in response to urinary tract obstruction, and protects against ischemia/reperfusion injury in many cell types [1, 3, 4]. Aim. To obtain bioactive recombinant human HB-EGF and investigate its proliferation capacity.
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Keywords
HB-EGF, recombinant protein, proliferation, tissue repair, conference materials
Citation
Didan, A. V. Heparin-binding EGF-like growth factor as a prospective mediator of tissue repair and regeneration / A. V. Didan, A. A. Siromolot, D. V. Kolybo // Biotechnologia Acta. - 2024. - Vol. 17, No 2. - Р. 33-35. - https://doi.org/10.15407/biotech17.02.033