Heparin-binding EGF-like growth factor as a prospective mediator of tissue repair and regeneration

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dc.contributor.authorDidan, A.en_US
dc.contributor.authorSiromolot, Andriyen_US
dc.contributor.authorKolybo, Denysen_US
dc.date.accessioned2025-03-11T07:20:00Z
dc.date.available2025-03-11T07:20:00Z
dc.date.issued2024
dc.description.abstractHeparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family. It contains EGF-like and heparin-binding domains allowing interactions with heparin and cell-surface heparin sulfate. [1] It can activate human epidermal growth factor receptors 1 and 4 resulting in a multitude of cell responses, including cellular proliferation, migration, adhesion, and differentiation. HB-EGF levels can increase in response to different forms of injuries as well as extracellular stimuli, such as lysophosphatidic acid, retinoic acid, and 17-estradiol [2]. HB-EGF plays a critical role in tissue repair and regeneration. It promotes cutaneous wound healing, hepatocyte proliferation after partial hepatectomy, intestinal anastomosis strength, alveolar regeneration after pneumonectomy, neurogenesis after ischemic injury, bladder wall thickening in response to urinary tract obstruction, and protects against ischemia/reperfusion injury in many cell types [1, 3, 4]. Aim. To obtain bioactive recombinant human HB-EGF and investigate its proliferation capacity.en_US
dc.identifier.citationDidan, A. V. Heparin-binding EGF-like growth factor as a prospective mediator of tissue repair and regeneration / A. V. Didan, A. A. Siromolot, D. V. Kolybo // Biotechnologia Acta. - 2024. - Vol. 17, No 2. - Р. 33-35. - https://doi.org/10.15407/biotech17.02.033en_US
dc.identifier.issn2410-7751
dc.identifier.issn2410-776X
dc.identifier.urihttps://doi.org/10.15407/biotech17.02.033
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/33878
dc.language.isoenen_US
dc.relation.sourceBiotechnologia Actaen_US
dc.statusfirst publisheden_US
dc.subjectHB-EGFen_US
dc.subjectrecombinant proteinen_US
dc.subjectproliferationen_US
dc.subjecttissue repairen_US
dc.subjectconference materialsen_US
dc.titleHeparin-binding EGF-like growth factor as a prospective mediator of tissue repair and regenerationen_US
dc.typeConference materialsen_US
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Кафедра лабораторної діагностики біологічних систем